Introduction and Context

Nowadays the interest on mathematical models applied to biomedical problems has greatly increased; in particular the need of a better understanding and knowledge of quantities in the medical context has raised exponentially the complexity of mathematics that is employed for the description of such physical systems.

Thanks to its special connection to the brain and its accessibility to measurements, the eye provides a unique window on the brain, thereby offering non-invasive access to a large set of potential biomarkers that might help in the early diagnosis and clinical care of Neuro-Degenerative Diseases.

This project aims at developing a reliable and efficient computational framework to simulate and predict the functioning and the connection between the eye and the brain.

The ocular contribution is voted to implement the tissue perfusion, the biomechanics and the fluid dynamics within the eye. These three different aspects of the same physical problem have to be properly connected and every step has to be verified and validated in the interest of a medical application.

We have presented our work including writing some articles and abstract in the prospect of promulgating our research and having stimulating feedbacks to better develop the model.

The presentation of this project will be articulated in three parts: the guide to the user interface, the employment of the model on a virtual patient database, the description of the core of the model with a list of applications where the Ocular Mathematical Virtual Simulator has been used for research purposes.